![]() ![]() Moreover, the degree to which symptom severity improved was associated with increased metabolic dysregulation in terms of body weight, body mass index (BMI), total cholesterol, LDL cholesterol, and HDL cholesterol, "suggesting that the most efficacious antipsychotics are associated with the greatest metabolic disturbance," Pillinger and colleagues said. "Interestingly, some of the drugs were shown to perform better than placebo on some metabolic measures: for instance, when compared with placebo, lurasidone led to reductions in glucose, cariprazine to reductions in LDL cholesterol, and aripiprazole and brexpiprazole to increases in HDL cholesterol," the researchers said. However, certain medications were associated with different adverse metabolic effects such that, for example, risperidone (Risperdal) and paliperidone (Invega) were linked with weight gain but not increased fasting blood glucose, the researchers wrote in their study online in Lancet Psychiatry. ![]()
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